Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size

Sherazaan D Ismail,Catherine Riou,Sarah B Joseph,Nancie M Archin,David M Margolis,Alan S Perelson,Tyler Cassidy,Melissa-Rose Abrahams,Matthew Moeser,Olivia D Council,Lyle R McKinnon,Farzana Osman,Quarraisha Abdool Karim,Salim S Abdool Karim, Ronald Swanstrom,Carolyn Williamson,Nigel J Garrett,Wendy A Burgers

CLINICAL INFECTIOUS DISEASES（2021）

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摘要

Understanding what shapes the latent human immunodeficiency virus type 1 (HIV-1) reservoir is critical for developing strategies for cure. We measured frequency of persistent HIV-1 infection after 5 years of suppressive antiretroviral therapy initiated during chronic infection. Pretreatment CD8(+) T-cell activation, nadir CD4 count, and CD4:CD8 ratio predicted reservoir size.

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关键词

HIV-1, replication-competent virus, reservoir, T-cell activation

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