Functional Abdominal Pain Disorders and Patient- and Parent-Reported Outcomes in Children with Inflammatory Bowel Disease in Remission.

Background: Chronic abdominal pain occurs frequently in pediatric patients with inflammatory bowel disease (IBD) in remission. Aims: To assess the prevalence and factors associated with Functional Abdominal Pain Disorders among IBD children in remission (IBD-FAPD). Methods: Patients with IBD for symbolscript 1 year, in clinical remission for symbolscript 3 months were recruited from a National IBD network. IBD-FAPDs were assessed using the Rome III questionnaire criteria. Patient-or parent-reported outcomes were assessed. Results: Among 102 included patients, 57 (56%) were boys, mean age (DS) was 15.0 symbolscript 2.0) years and 75 (74%) had Crohn's disease. Twenty-two patients (22%) had at least one Functional Gastrointestinal Disorder among which 17 had at least one IBD-FAPD. Past severity of disease or treatments received and level of remission were not significantly associated with IBD-FAPD. Patients with IBD-FAPD reported more fatigue (peds-FACIT-F: 35.9 symbolscript 9.8 vs. 43.0 symbolscript 6.9, p symbolscript 0.01) and a lower HR-QoL (IMPACT III: 76.5 symbolscript 9.6 vs. 81.6 symbolscript 9.2, p symbolscript 0.04) than patients without FAPD, and their parents had higher levels of State and Trait anxiety than the other parents. Conclusions: Prevalence of IBD-FAPD was 17%. IBD-FAPD was not associated with past severity of disease, but with fatigue and lower HR-QoL. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.