Activation Of 8-17 Dnazyme With Extra Functional Group At Conserved Residues Is Related To Catalytic Metal Ion

Wenjie Zhang,Yang Li,Shanshan Du,Zhilong Chai,Junlin He

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2021）

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摘要

In 8-17 DNAzyme, the end loop A(6)G(7)C(8) is a highly conserved motif. Here we reported an activation approach by specific chemical modifications on A6 and C8 for more efficient Ca2+-mediated reaction. The importance of the end loop was further highlighted and its critical conservation broken for more powerful catalysts.

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关键词

8-17 DNAzyme, Functional group, Observed rate constant, Metal ion dependence, Catalytic core

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