Gold(I)-Catalyzed Synthesis Of 3-Sulfenyl Pyrroles And Indoles By A Regioselective Annulation Of Alkynyl Thioethers
ACS CATALYSIS(2021)
摘要
The combination of nucleophilic nitrenoids and pacid catalysis has emerged as a powerful tool in heterocycle synthesis. Accessing more varied heterocycle-substitution patterns by maintaining the same reaction pathways across different alkynes remains a challenge. Here we show that Au(I) catalysis of isoxazole-based nitrenoids with alkynyl thioethers provides controlled access to (3 + 2) annulation by a regioselective addition beta to the sulfenyl group. The reaction with isoxazole-containing nitrenoids delivers sulfenylated pyrroles and indoles as single regioisomers bearing useful functional groups and structural variety.
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关键词
gold, pyrroles, nitrenoid, annulation, thioether, indole
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