AB0395 RENAL INVOLVEMENT IN HENOCH-SCHÖNLEIN PURPURA

Background:Henoch-Schönlein purpura (HSP), also known as rheumatic purpura, is an immune complex vasculitis affecting small vessels with dominant IgA deposits. Clinical manifestations mainly involve cutaneous purpura, arthralgias and/or arthritis, acute enteritis and glomerulonephritis. HSP is more common among children than adults. Kidney damage is the principal prognostic determinant in HSP. The aim of this study is to evaluate the renal manifestations of HSP.Objectives:The aim of this study is to evaluate the renal manifestations of HSP.Methods:This was a retrospective study of 35 patients with diagnosed HSA, who were admitted between the time period may 2008 and november 2018. All of these patients met the American College of Rheumatology classification criteria for a diagnosis of HSP. Renal involvement was defined as the presence of proteinuria or hematuria.Results:The study group consisted of 35 patients, 20 women (57%) and 15 men (43%). The mean age was 48.8± 18.7 years. The incidence rates of skin, joint, gastrointestinal and central nervous system involvement were 91.4, 77.1, 54.2 and 2.8%, respectively. Elevated serum IgA levels occurred in 5.7 %. Six patients (17.1%) were given corticosteroids during the first 3 months of their HSP, which were indicated for severe gastrointestinal (n=5) or renal involvement (n=1). Eighteen of the thirty five patients (51.42%) had renal involvement. There were 12 women and six men. All patients had proteinuria (100%). Hematuria has been identified in 11 patients (61.1%) and renal insufficiency in 4 patients (22.2%). The renal involvement was mainly detected in the first month. Renal biopsy was affected in four patients (22.2%). An endocapillary glomerulonephritis was found in 3 patients and an extra capillary necrotizing glomerulonephritis in one patient. The immunofluorescence showed the presence of IgA deposits in 4 patients.Conclusion:Renal involvement dominates the prognosis for the disease. The most common clinical expression is the association of microscopic hematuria with proteinuria.Disclosure of Interests:None declared