Integration of metabolomics and transcriptomics reveals major metabolic pathways and potential biomarkers involved in aging mice with type 2 diabetes mellitus

To the Editor: Aging can cause changes in human metabolic capacity and metabolic syndrome is one of the important causes of type 2 diabetes mellitus (T2DM). In recent years, T2DM has become one of the top ten killers of humans. T2DM has been reported in ≥25% of the population aged over 65 years. The liver is the most important metabolic center and its metabolic disorders are associated with T2DM. However, studies on liver metabolic disorders in older adult patients with T2DM are limited. Therefore, it is necessary to analyze liver metabolism in these patients in combination with modern omics methods. In this study, we integrated metabonomics and transcriptomics analyses to analyze the specific metabolites and genes that change in the liver of aging mice with T2DM, and to provide a theoretical basis for the treatment of older adult patients with T2DM.