A Facile Chemoenzymatic Synthesis Of Sars-Cov-2 Glycopeptides For Probing Glycosylation Functions

Guanghui Zong,Chao Li,Sunaina Kiran Prabhu,Roushu Zhang,Xiao Zhang,Lai-Xi Wang

CHEMICAL COMMUNICATIONS（2021）

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摘要

Glycosylation plays important roles in SARS-CoV-2 infection. We describe here a facile chemoenzymatic synthesis of core-fucosylated N-glycopeptides derived from the SARS-CoV-2 Spike protein and their binding with glycan-dependent neutralizing antibody S309 and human lectin CLEC4G. The synthetic glycopeptides provide tools for further functional characterization of viral glycosylation.

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关键词

glycosylation functions,facile chemoenzymatic synthesis,sars-cov

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