Immunoglobulin GM and KM allotypes are associated with antibody responses to Pseudomonas aeruginosa antigens in chronically infected cystic fibrosis patients

Janardan P Pandey,Aryan M Namboodiri,Paul J Nietert,Michael R Knowles,Rhonda G Pace, Gerald B Pier

Journal of Cystic Fibrosis（2021）

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摘要

•GM and KM genotypes influence IgG antibody responses to P. aeruginosa antigens•They also influence antibody responsiveness to the broadly-conserved surface polysaccharide poly-N-acetyl-D-glucosamine (PNAG) expressed by many microbial pathogens relevant to CF pathology•Some GM and KM genotypes interactively/epistatically contribute to the antibody responses to the P. aeruginosa alginate antigen

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关键词

GM/KM allotypes,IgG antibodies,Pseudomonas aeruginosa,Cystic fibrosis

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