Integrated molecular and affiliation network analysis: Core-periphery social clustering is associated with HIV transmission patterns

•Affiliation networks are integrated with molecular data to examine HIV transmission.•Core-peripheral structure in venue affiliation is associated with HIV transmission.•Popular social venues potentiate sexual affiliation network of minority young MSM.•Molecular and affiliation network approach informs effective network interventions.•A surveillance-research-community partnership is important to address ethical issues.