Detection of EGFR mutations in liquid biopsy samples using allele-specific quantitative PCR: A comparative real-world evaluation of two popular diagnostic systems

Adam Szpechcinski,Maciej Bryl,Piotr Wojcik,Grzegorz Czyzewicz,Emil Wojda,Piotr Rudzinski,Katarzyna Duk,Joanna Moes-Sosnowska,Krystyna Maszkowska-Kopij,Renata Langfort,Aleksander Barinow-Wojewodzki,Joanna Chorostowska-Wynimko

Advances in Medical Sciences（2021）

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摘要

Cobas was superior to therascreen for detection of plasma EGFR mutations in advanced NSCLC. Plasma cfDNA EGFR mutation analysis is complex; therefore, the diagnostic accuracy of commercially available assays should be validated.

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关键词

Allele-specific qPCR,EGFR mutations,Liquid biopsy,Non-small cell lung cancer,Tyrosine kinase inhibitors

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