The structure of the cysteine-rich region from human histone-lysine N-methyltransferase EHMT2 (G9a)

Keshia M Kerchner,Tung-Chung Mou,Yizhi Sun,Domniţa-Valeria Rusnac,Stephen R Sprang,Klára Briknarová

Journal of Structural Biology: X（2021）

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摘要

•EHMT1/2 histone lysine methyltransferases contain a unique cysteine-rich region (CRR).•The structure of the CRR from human EHMT2 was determined by X-ray crystallography.•The CRR adopts an unusual compact fold that contains an embedded RING domain.

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关键词

Zinc-binding motif,RING domain,Protein interaction,Chromatin targeting,X-ray crystallography

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