Serotonin drives striatal synaptic plasticity in a sex-related manner

Federica Campanelli,Gioia Marino,Noemi Barsotti,Giuseppina Natale,Valeria Calabrese,Antonella Cardinale,Veronica Ghiglieri,Giacomo Maddaloni,Alessandro Usiello,Paolo Calabresi,Massimo Pasqualetti,Barbara Picconi

Neurobiology of Disease（2021）

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摘要

•Tph2 catalyzes the rate-limiting step in 5-HT biosynthesis via subsequent decarboxylation.•Neurotransmitter systems (DA and 5-HT) are differently regulated between sexes.•Serotonergic and dopaminergic interplay modulates synaptic activity within the striatal nucleus.•Tph2 gene dosage exerts a primary role in modulating bidirectional synaptic plasticity in a sex-related manner.

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关键词

Serotonin,Tph2,Dopamine,Synaptic plasticity,Striatum,Functional recovery

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