Iguratimod decreases bleomycin-induced pulmonary fibrosis in association with inhibition of TNF-α in mice

Siqi Shao,Ziye Qu,Yiwen Liang,Yan Xu,Dongmei Zhou,Danhua Li,Ying Zhang,Songlou Yin

International Immunopharmacology（2021）

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摘要

•IGU decreased pulmonary inflammation and fibrosis induced by bleomycin.•IGU decreased production of TNF-α and activation of NF-κB.•IGU ameliorated severe pulmonary fibrosis induced by injecting exogenous TNF-α.

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关键词

Iguratimod,Pulmonary fibrosis,Tumor necrosis factor-α

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