Agreement Between Automated and Clinically Reported Manual ROI-Based MR Elastography Liver Stiffness Measurements in Children and Young Adults

MR elastography (MRE) typically requires manual ROI placement to generate liver shear stiffness measurements. Among 419 patients (primarily children and young adults), a computer-based automated MRE processing tool and clinically reported manual ROI-based measurements generated similar results (mean bias = 0.13 kPa). The intraclass correlation coefficient was 0.94 and was at least 0.90 across common indications in male and female patients and in patients with and without elevated liver fat fraction. Automated analysis may promote postprocessing standardization and decrease reporting variability.