An integrated biophysical model for predicting the clinical pharmacokinetics of transdermally delivered compounds

Mahadevabharath R Somayaji,Debarun Das,Harsha Teja Garimella,Carrie L German,Andrzej J Przekwas,Laurent Simon

European Journal of Pharmaceutical Sciences（2021）

引用 8|浏览5

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摘要

•A holistic skin model linked to a systems pharmacology model is presented.•The skin model predicts the permeation of tool compounds.•The effects of chemical penetration enhancers and hair follicles are considered.•The integrated model predicts the pharmacokinetics of transdermally delivered drugs.•The model predictions are validated with clinical data.

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关键词

Transdermal,Dermal,Absorption,Integrated,Model,Computational,PBPK,Pharmacology,Skin,Patch

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