SARS-CoV-2 Neutralization Resistance Mutations in Patient with HIV/AIDS, California, USA.

Seth A Hoffman,Cristina Costales,Malaya K Sahoo,Srikanth Palanisamy,Fumiko Yamamoto,ChunHong Huang,Michelle Verghese,Daniel A Solis,Mamdouh Sibai,Aruna Subramanian,Lucy S Tompkins,Philip Grant,Robert W Shafer,Benjamin A Pinsky

EMERGING INFECTIOUS DISEASES（2021）

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摘要

We report persistent severe acute respiratory syndrome coronavirus 2 infection in a patient with HIV/AIDS; the virus developed spike N terminal domain and receptor binding domain neutralization resistance mutations. Our findings suggest that immunocompromised patients can harbor emerging variants of severe acute respiratory syndrome coronavirus 2.

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2019 novel coronavirus disease,COVID-19,California,HIV/AIDS,SARS-CoV-2,United States,antimicrobial resistance,coronavirus disease,coronaviruses,immunocompromised,respiratory infections,severe acute respiratory syndrome coronavirus 2,viral evolution,viruses,zoonoses

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