Longitudinal Changes of Local Field Potential Oscillations in Nucleus Accumbens and Anterior Limb of the Internal Capsule in Obsessive- Compulsive Disorder

Anterior limb of the internal capsule (ALIC) deep brain stimulation (DBS) shows stable efficacy in refractory obsessive-compulsive disorder (OCD) ( 1 Graat I. Mocking R. Figee M. Vulink N. de Koning P. Ooms P. et al. Long-term outcome deep brain stimulation of the ventral part of the anterior limb of the internal capsule in a cohort of 50 patients with treatment-refractory obsessive-compulsive disorder. Biol Psychiatry. 2021; 90: 714-720 Abstract Full Text Full Text PDF PubMed Scopus (27) Google Scholar ). Recently, several DBS connectivity studies in OCD have investigated the effect of DBS on the structural and functional connectivity in the nucleus accumbens (NAc) and ALIC ( 2 Li N. Baldermann J.C. Kibleur A. Treu S. Akram H. Elias G.J.B. et al. A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder. Nat Commun. 2020; 11: 3364 Crossref PubMed Scopus (165) Google Scholar , 3 Baldermann J.C. Melzer C. Zapf A. Kohl S. Timmermann L. Tittgemeyer M. et al. Connectivity profile predictive of effective deep brain stimulation in obsessive-compulsive disorder. Biol Psychiatry. 2019; 85: 735-743 Abstract Full Text Full Text PDF PubMed Scopus (148) Google Scholar , 4 Tyagi H. Apergis-Schoute A.M. Akram H. Foltynie T. Limousin P. Drummond L.M. et al. A randomized trial directly comparing ventral capsule and anteromedial subthalamic nucleus stimulation in obsessive-compulsive disorder: Clinical and imaging evidence for dissociable effects. Biol Psychiatry. 2019; 85: 726-734 Abstract Full Text Full Text PDF PubMed Scopus (126) Google Scholar , 5 Li N. Hollunder B. Baldermann J.C. Kibleur A. Treu S. Akram H. et al. A unified functional network target for deep brain stimulation in obsessive-compulsive disorder. Biol Psychiatry. 2021; 90: 701-713 Abstract Full Text Full Text PDF PubMed Scopus (33) Google Scholar ). For electrophysiological effects, we attempt to examine the local effects of effective DBS in the NAc/ALIC by long-term recording the local field potentials (LFPs) in a case of OCD.