What happens after menopause? (WHAM): A prospective controlled study of vasomotor symptoms and menopause-related quality of life 12 months after premenopausal risk-reducing salpingo-oophorectomy

•Vasomotor symptoms increase by 3 months following premenopausal RRSO and persist but do not worsen by 12 months.•Almost all women report these vasomotor symptoms as “mild”.•Hormone therapy reduces but does not resolve vasomotor symptoms after RRSO.•Hormone therapy improves menopause related quality of life but not to pre-RRSO levels.