Sex differences in zonulin in affective disorders and associations with current mood symptoms

A Maget,N Dalkner,C Hamm,S A Bengesser,F T Fellendorf,M Platzer,R Queissner,A Birner,M Lenger,S Mörkl, A Kohlhammer-Dohr,A Rieger, M Seidl, L Mendel,T Färber,L Wetzlmair, K Schwalsberger, D V Amberger-Otti, H Schöggl,T Lahousen, B Leitner-Afschar, R Unterweger,S Zelzer,H Mangge, E Z Reininghaus

Journal of Affective Disorders（2021）

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摘要

•Serum zonulin was significantly higher in females than in men.•Serum zonulin was independent from affective status in mood disorders.•As a regulator of intestinal permeability, zonulin acts as a key player.•Zonulin may influence neuropsychiatric entities by loosening the BBB.•Women may be prone to develop depression due to higher zonulin levels.

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关键词

Zonulin,Affective disorders,Intestinal permeability,Depression,Bipolar disorder,Inflammation

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