Once daily 300 mg aspirin with compression versus compression alone in patients with chronic venous leg ulcers (ASPiVLU): A randomised, double-blinded, multicentre, placebo-controlled, clinical trial

•Daily 300 mg aspirin dose did not improve time to healing at 12 or 24 weeks or decrease recurrence rates when used as an adjuvant to compression.•Effect of aspirin on inflammation markers provided a unique analysis using ulceration characteristics and haematological factors.•Aspirin may affect inflammation processes implicated in venous leg ulcer recurrence through inducing rapid reductions in Interlukin-7.