Biogenic silver nanoparticles (AgNp-Bio) reduce Toxoplasma gondii infection and proliferation in HeLa cells, and induce autophagy and death of tachyzoites by apoptosis-like mechanism

Raquel Arruda da Silva Sanfelice,Bruna Taciane da Silva Bortoleti,Fernanda Tomiotto-Pellissier,Taylon Felipe Silva,Larissa Rodrigues Bosqui,Gerson Nakazato,Pablo Menegon Castilho,Luiz Daniel de Barros,João Luis Garcia,Danielle Lazarin-Bidóia,Ivete Conchon-Costa,Wander Rogério Pavanelli,Idessania Nazareth Costa

Acta Tropica（2021）

引用 7|浏览3

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摘要

•AgNp-Bio showed reduction in tachyzoites of T. gondii in cells infected.•AgNp-Bio showed directly inhibitory activity on tachyzoites.•AgNp-Bio treatment induce depolarization of the mitochondrial membrane potencial.•AgNp-Bio increase in ROS production and accumulation of lipid bodies.•AgNp-Bio triggered an autophagic process and induce phosphatidylserine exposure.

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关键词

Toxoplasmosis,Biogenic silver nanoparticles (AgNp-Bio),Cytotoxicity,HeLa cells,Apoptosis-like

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