Improvement in Dysphagia Outcomes Following Clinical Target Volume Reduction in the De-ESCALaTE Study

M. Vreugdenhil,C. Fong, G. Iqbal,T. Roques,M. Evans, N. Palaniappan,H. Yang, L. O'Toole,P. Sanghera,C. Nutting,B. Foran,M. Sen,H. Al Booz,T. Fulton-Lieuw,M. Dalby,J. Dunn,A. Hartley, H. Mehanna

Clinical Oncology（2021）

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摘要

•An amendment during a randomised study allowed centres to adopt a contouring protocol with a reduced clinical target volume.•Use of the reduced clinical target volume was not associated with a statistically significant increase in local recurrence.•Use of the reduced target volume was associated with improved swallowing outcomes.

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关键词

Chemoradiation,clinical target volume,MDADI,oropharyngeal cancer,swallowing

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