Predicting Disordered Gambling Across Adolescence and Young Adulthood from Polygenic Contributions to Big 5 Personality Traits in a UK Birth Cohort

Polygenic contributions to low agreeableness and high neuroticism appear to predict two measures of disordered gambling (problem gambling severity index and life-time assessment of DSM-IV pathological gambling symptoms). Polygenic scores for neuroticism interact with age to suggest that the positive association becomes stronger from adolescence through young adulthood.