ASTE1 cutting to block DNA end resection
NATURE CELL BIOLOGY（2021）
摘要
Cells rely on two main pathways to repair DNA lesions, homologous recombination and non-homologous end-joining, and how they decide to use one machinery over the other is not clear. A recent study identifies ASTE1 as a regulator controlling pathway choice.
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关键词
Cancer therapeutic resistance,Double-strand DNA breaks,Life Sciences,general,Cell Biology,Cancer Research,Developmental Biology,Stem Cells
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