Beyond targeted protein degradation: LD·ATTECs clear cellular lipid droplets

AuTophagy-TEthering Compounds (ATTECs) are a novel class of bifunctional molecules proposed to hijack the autophagosomal pathway for the degradation of potentially any cellular components in addition to proteins. Targeting stored fats in cells with LD.ATTECs suggests a novel approach to combating diseases implicating accumulation of lipid droplets, such as obesity, cardiovascular diseases, or cancer.