Reduced anaphylactic potential of denatured pullulan-conjugated Cry j 1

Daichi Utsumi, Takeru Sugawara, Kosumo Hashida, Yuki Yasuhara,Koji Fujinami,Kaare Lund,Katsuyo Ohashi-Doi

International Immunopharmacology（2021）

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摘要

•Denatured pullulan-conjugated Cry j 1 (Dn p-Cry j 1) possessed reduced anaphylactic potential.•The reduced anaphylactic potential compared to native Cry j 1 (n Cry j 1) was achieved by two-step process.•Dn p-Cry j 1 is proposed as a candidate for next-generation Japanese cedar allergy immunotherapy.

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关键词

Allergy immunotherapy,Subcutaneously immunotherapy,Japanese cedar pollen,Hypoallergen,Passive cutaneous anaphylaxis

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