Drug delivery strategies in maximizing anti-angiogenesis and anti-tumor immunity

•Metronomic chemotherapy is optimized with tuned drug doses and drug-free breaks.•Innate immunity can be just as essential in antitumor efficacy as adaptive.•Conventional maximum tolerated dose administration can often be immunosuppressive.•Optimal drug scheduling may vary based on drug mechanism/target and cancer type.•Metronomic chemotherapy may be delivered with current biomaterials for clinical ease.