Long Term Survival With Regorafenib: REALITY (Real Life in Italy) Trial - A GISCAD Study

Clinical Colorectal Cancer(2021)

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摘要
•Regorafenib-treated metastatic colorectal cancer patients with overall survival (OS) ≥ 6 months.•Absence of liver progression and dose/schedule changes: longer OS and progression free survival.•Median OS: 10.8 months longer in absence of liver progression and treatment changes.•Median progression free survival: 7.4 months longer in the same favorable group.•Treatment tolerability and toxicity management were confirmed as crucial factors.
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关键词
Metastatic colorectal cancer,Long term survivors,Liver progression,Treatment modification,Tolerability
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