Variability in tuition and curriculum among allopathic and osteopathic medical schools in the United States

•A cross-sectional analysis of 151 Allopathic and 37 Osteopathic U.S. medical schools were assessed for variations in mean in-state tuition (MIST), preclerkship curricula, and curriculum features.•Allopathic and Osteopathic medical schools demonstrated variable tuition even after adjusting for the cost of living (COL), and exhibited the greatest MIST in the Northeast and West regions, respectively.•Allopathic medical schools with a discipline-based exhibited significantly greater MIST, whereas those with a team-based curriculum were significantly reduced.•Allopathic medical schools requiring a research/scholarly project or global health elective (GHE) exhibited significantly greater adjusted MIST than those that did not.•Future studies may consider investigating the effect of academic match results, funding/resources, and student quality of life on MIST of Allopathic and Osteopathic medical schools.