Pravastatin attenuates sepsis-induced acute lung injury through decreasing pulmonary microvascular permeability via inhibition of Cav-1/eNOS pathway

•Pravastatin alleviates septic ALI via reducing microvascular permeability.•Pravastatin inhibits inflammation and apoptosis in septic ALI.•Pravastatin enhances the expression of junction proteins.•Cav-1/eNOS pathway is involved in the protective mechanism of pravastatin in septic ALI.