Use and application of plasma microRNA in predicting brain metastasis of lung adenocarcinoma

The invention discloses use and application of plasma microRNA in predicting brain metastasis of lung adenocarcinoma. It is found that hsa-mir-6850-5p has a significant correlation with brain metastasis in lung adenocarcinoma, and plays an important role in brain metastasis of lung adenocarcinoma. Therefore, detecting of the content level of hsa-mir-6850-5p is used to predict the risk of brain metastasis in patients with lung cancer. It is further found that hsa-mir-6850-5p can improve the proliferation, migration and invasion ability of lung cancer cells, and lung adenocarcinoma cells may secrete hsa-mir-6850-5p outside the cells through exosomes. The invention provides a corresponding detection or treatment kit based on the findings.