Exploiting a key transcriptional dependency: ZMYND8 and IRF8 in AML.

Samuel J Taylor,Sriram Sundaravel,Ulrich Steidl

Molecular cell（2021）

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摘要

In this issue of Molecular Cell, Cao et al. (2021) report that AML cells are specifically addicted to an IRF8-MEF2D gene expression network. Furthermore, they identify a chromatin reader, ZMYND8, as the upstream regulator of the IRF8-MEF2D program whose activity is critical for AML cell survival.

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