RNA m 6 A Modification Plays a Key Role in Maintaining Stem Cell Function in Normal and Malignant Hematopoiesis.

N-methyladenosine (mA) is a commonly modification of mammalian mRNAs and plays key roles in various cellular processes. Emerging evidence reveals the importance of RNA mA modification in maintaining stem cell function in normal hematopoiesis and leukemogenesis. In this review, we first briefly summarize the latest advances in RNA mA biology, and further highlight the roles of mA writers, readers and erasers in normal hematopoiesis and acute myeloid leukemia. Moreover, we also discuss the mechanisms of these mA modifiers in preserving the function of hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs), as well as potential strategies for targeting mA modification related pathways. Overall, we provide a comprehensive summary and our insights into the field of RNA mA in normal hematopoiesis and leukemia pathogenesis.