Inhibiting PP2Ac alpha Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis

This article is aimed at exploring the relationship between the phosphatase 2A catalytic subunit C alpha (PP2Ac alpha, encoded by PPP2CA) and methyltransferase-like 3 (METTL3) in the malignant progression of gastric cancer (GC). Through analyzing the bioinformatics database and clinical tissue immunohistochemistry results, we found that abnormal PP2Ac alpha and METTL3 levels were closely related to the malignant progression of GC. To explore the internal connection between PP2Ac alpha and METTL3 in the progression of GC, we carried out cellular and molecular experiments and finally proved that PP2Ac alpha inhibition can upregulate METTL3 levels by activating ATM activity, thereby promoting the malignant progression of GC.