Hyaluronic acid-coated chitosan nanoparticles as carrier for the enzyme/prodrug complex based on horseradish peroxidase/indole-3-acetic acid: Characterization and potential therapeutic for bladder cancer cells

•Hyaluronic acid-coated chitosan nanoparticles (CS/HA NP) were successfully prepared.•Indole-3-acetic acid-IAA and Horseradish Peroxidase-HRP were encapsulated on CS/HA NP.•Characterization confirms the formation of nanoparticles and biomolecules presence.•IAA-CS/HA NP presents a bimodal release profile of IAA at pH 5.5.•HRP-CS/HA NP associated IAA- CS/HA NP is cytotoxic in vitro (carcinoma cell line-T24).