Design of long acting invasomal nanovesicles for improved transdermal permeation and bioavailability of asenapine maleate for the chronic treatment of schizophrenia

•Invasomes containing limonene had superior transdermal permeation compared to other carriers.•Asenapine bioavailability has been enhanced from 3.5% to 54.5%.•Asenapine transdermal application using invasomes achieved a long action till 72 h.