Obstructive sleep apneas naturally occur in mice during REM sleep and are highly prevalent in a mouse model of Down syndrome

Maria Lavinia Bartolucci,Chiara Berteotti,Sara Alvente,Stefano Bastianini,Sandra Guidi,Viviana Lo Martire,Gabriele Matteoli,Alessandro Silvani,Fiorenza Stagni,Marcello Bosi,Giulio Alessandri-Bonetti,Renata Bartesaghi,Giovanna Zoccoli

Neurobiology of Disease（2021）

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摘要

•Mice physiologically exhibit both central sleep apneas and obstructive sleep apneas.•Obstructive sleep apneas appear almost exclusively during rapid-eye-movement-sleep.•Obstructive sleep apneas are prevalent in Ts65Dn, a mouse model of Down syndrome.•Mice models help to understand the pathophysiology of sleep-disordered breathing.

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关键词

Apneas,Mice,Down syndrome,Breathing,Respiratory disorder

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