Lasibidoupins A and B, two new compounds from the stems of Lasianthus bidoupensis V.S. Dang & Naiki.

Natural product research(2021)

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摘要
From the stems, two new compounds, including one new 9,10-anthraquinone, lasibidoupin A (), and one new 6,7-benzocoumarin, lasibidoupin B (), together with one known compound, 11--methyldamnacanthol () were isolated using chromatographic method. Their structures were determined by extensive HRMS, and NMR assignments. Compound was reported for the first time from this species. New compounds ( & ) were tested for the cytotoxicity against three human cancer cell lines (MCF-7, HeLa, and NCI-H460) by SRB assay. As results, & exhibited significant cytotoxic activity against all cancer cell lines (IC ranged from 0.058± 0.003 to 0.177 ± 0.014 μM).
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关键词
6,7-benzocoumarin,9,10-anthraquinone,Lasianthus bidoupensis,cytotoxic activity,lasibidoupin A,lasibidoupin B
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