TEP1 is a risk gene for sporadic cerebral palsy.

Cerebral palsy (CP) is a nonprogressive dyskinesia syndrome caused by early brain injury,with an incidence of approximately 2.0-3.5/1000 live births worldwide (Li et al.,2021;Moreno-De-Luca et al.,2021).Currently,there are more than 300,000 children aged 0-6 years diagnosed with CP in China (Liu et al.,1999;Yang et al.,2021),thus making it one of the most common debilitating dis-eases affecting children.Increasing evidence supports genetic fac-tors as one of the causes in the pathogenesis of CP (Moreno-De-Luca et al.,2012).To date,only a few pathogenic genes have been identified (Moreno-De-Luca et al.,2012;Jin et al.,2020;Li et al.,2021 ;Moreno-De-Luca et al.,2021),but previous estimates suggest that hundreds of genes potentially associated with CP remain undis-covered (O'Callaghan et al.,2009;Fahey et al.,2017).