Toward personalized medicine in connectomic deep brain stimulation

•We advocate a shift from disease- to symptom-centric connectomic DBS.•We propose personalization to individual symptom profiles to improve effectiveness.•Symptom network targets can be derived via group-level DBS analyses.•Relevant symptom network templates could then be matched to individual circuitry.•Stimulation targets may be optimized via individualized blends of symptom networks.