Comparison of microbial composition of cough swabs and sputum for pathogen detection in patients with cystic fibrosis

Dominic Fenn,Mahmoud I Abdel-Aziz,Paul Brinkman,Renate Kos,Anne H Neerincx,Josje Altenburg,E Weersink,Eric G Haarman,Suzanne W J Terheggen-Lagro,Anke H Maitland-van der Zee,Lieuwe D J Bos

Journal of Cystic Fibrosis（2022）

引用 6|浏览25

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摘要

•Next generation sequencing and amplicon sequence variant (ASV) analysis of cough swabs provide an inaccurate diagnosis of lower respiratory tract colonization.•Culture independent analysis shows high idiosyncrasy for both cough swabs and sputum.•There remains a need for non-invasive diagnostic tools to identify colonisation with pathogens, previously reliant on sputum, that that cannot be filled with analysis of cough swabs.

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关键词

Microbiome,Cystic fibrosis,Pulmonary infection,Pseudomonas aeruginosa,Next generation sequencing

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