Tumor volumes as a predictor of response to the anti-EGFR antibody drug conjugate depatuxizumab mafadotin.

Hui K Gan,Sagun Parakh,Andrew B Lassman,Aidan Seow,Eddie Lau,Sze Ting Lee,Malaka Ameratunga,Yuliya Perchyonok,Diana Cao,Ingrid J G Burvenich,Graeme J O'Keefe,Angela Rigopoulos,Erica Gomez,David Maag,Andrew M Scott

Neuro-oncology advances（2021）

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摘要

Both preclinical and clinical data showed intra-tumoral concentration and efficacy of Depatux-m inversely correlated with tumor size. This finding merit further investigation with pretreatment tumor volume as a predictor for response to ADCs, in both gliomas and other solid tumors.

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关键词

GBM,depatuxizumab mafadotin,tumor volume

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