Pullulan film incorporated with nanocapsules improves pomegranate seed oil anti-inflammatory and antioxidant effects in the treatment of atopic dermatitis in mice

Verônica Ferrari Cervi,Camila Parcianello Saccol,Marcel Henrique Marcondes Sari,Carolina Cristóvão Martins,Lucas Saldanha da Rosa,Bruna Dias Ilha,Fábio Zovico Soares,Cristiane Luchese,Ethel Antunes Wilhelm,Letícia Cruz

International Journal of Pharmaceutics（2021）

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摘要

•Pullulan nano-based pomegranate seed oil (PSO) film for cutaneous application was developed.•The prepared films formulations were flexible and highly occlusive.•Films with free PSO and PSO nanocapsules attenuated skin injury and mechanical hypernociception.•Only the PSONCF treatment modulated the inflammatory and oxidative parameters.

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关键词

Vegetable oil,Polymeric films,Atopy,Inflammation,Antioxidants,Cutaneous application,Nanotechnology

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