Impact of High Serum Levels of MMP-7, MMP-9, TGF-β and PDGF Macrophage Activation Markers on Severity of COVID-19 in Obese-Diabetic Patients.

Asmaa Nasr El-Din,Kamal Abd El-Sattar Ata,Abdelhady Ragab Abdel-Gawad,Nahed F Fahmy

Infection and drug resistance（2021）

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摘要

Macrophages were mainly polarized towards the M2 phenotype in obese-diabetic COVID-19 patients with significant upregulation of the pro-fibrotic markers MMP-7, MMP-9, PDGF, and TGF-β. Thus, high levels of MMP-7 and MMP-9 are associated with ARDS in severe COVID-19 disease among obese-diabetic patients.

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COVID-19,MMP-7,MMP-9,PDGF,TGF-β

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