WEE1i-ATRi combination therapy: a promising low-dose treatment for CCNE1-amplified gynecologic cancers
Cell reports Medicine（2021）
摘要
CCNE1 amplification is an oncogenic driver for many gynecologic cancers and is associated with poor patient outcomes. In this issue, Xu et al.(1) identify a combination therapy that is responsive to high CCNE1copy number ovarian and endometrial cancers using PDX models.
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