ISOLATION AND COMPERATIVE STUDY OF THE GROWTH INHIBITING THERMOSTABLE PROTEIN COMPLEX FROM THE BONE MARROW OF THE ADULT MICE.

The growth inhibiting thermostable protein complex (TPC) from the bone marrow cells of adult mice was isolated and partially characterized. A comparative analysis of TPC components was performed by polyacrylamide gel electrophoresis. It has been established that the complex isolated from the bone marrow of adult mice, like complexes obtained from other organs, contains two relatively high-molecular-weight and low-molecular-weight sub fractions of proteins. In addition, minor content of low molecular weight components was detected in bone marrow TPC. It has been established that the thermostable protein complex of adult mice bone marrow cells does not have the ability to inhibit the proliferation of homotypic cells. This may be due to the minor content of active component (low molecular weight subfraction) in the complex and the structural and functional properties of constantly renewable hematopoietic tissue, such as the nature of factors that regulate proliferation, their different cell penetration and the expression of membrane receptors.