Microstructural Alteration of Lumbosacral Nerve Roots in Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Insights From DTI and Correlations with Electrophysiological Parameters

Rationale and objectives: To detect the diffusion characteristics of lumbosacral nerve roots in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and further to explore their correlations with electrophysiological parameters of lower extremity nerves. Materials and methods: Eighteen CIDP patients and 18 age and sex-matched healthy volunteers were enrolled in this study from August 2019 to August 2020. Axial diffusion tensor imaging (DTI) of lumbosacral plexus was performed in all subjects and fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) of lumbosacral nerve roots were measured. Two-sample t test or Mann-Whitney U test was used to compare the difference of DTI parameters between two groups. Receiver operating characteristic curves were plotted to determine the diagnostic accuracy. All patients also underwent nerve conduction studies. Correlations between DTI parameters of lumbosacral nerve roots and electrophysiological parameters were analyzed with Pearson or Spearman coefficients. Results: CIDP patients showed significantly lower FA as well as higher AD, RD, and MD values of lumbosacral nerve roots (FA:0.24 +/- 0.054, 0.32 +/- 0.044; AD:2.31 +/- 0.256, 2.11 +/- 0.230 (x10(-3)mm(2)/s); RD:1.28 +/- 0.189, 1.13 +/- 0.106 (x10(-3)mm(2)/s); MD:1.68 +/- 0.268, 1.45 +/- 0.186 (x10(-3)mm(2)/s) in CIDP and control group, respectively, all p < 0.05). Receiver operating characteristic analysis showed among all DTI parameters, FA had the best diagnostic accuracy with an area under the curve of 0.914 and optimal cut-off value of 0.27. FA showed a positive correlation while RD showed a negative correlation with a conduction velocity of tibial and common peroneal nerves. RD also correlated positively with F-wave minimal latency of tibial nerves. Conclusion: DTI can be used to assess the microstructure alterations of lumbosacral nerve roots in CIDP patients. FA and RD may serve as potential markers reflecting the conduction function of tibial and common peroneal nerves.