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Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors

Anita C. Bellail,Hong Ri Jin,Ho-Yin Lo,Sung Han Jung, Chafiq Hamdouchi, Daeho Kim, Ryan K. Higgins,Maximilian Blanck,Carlos le Sage,Benedict C.S. Cross, Jing Li, Amber L. Mosley,Aruna B. Wijeratne,Wen Jiang, Manali Ghosh, Yin Quan Zhao,Paula M. Hauck,Anantha Shekhar,Chunhai Hao

Science Translational Medicine（2021）

引用 13|浏览14
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摘要
Small-molecule degraders of SUMO1 induce its ubiquitination and degradation through binding of CAPRIN1 in tumor cells in vitro and in vivo.
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关键词
sumo1,degradation,small-molecule,patient-derived
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