A deletion in the N gene may cause diagnostic escape in SARS-CoV-2 samples.

Silvia Zannoli,Giorgio Dirani,Francesca Taddei, Giulia Gatti, Ilaria Poggianti, Agnese Denicolò, Valentina Arfilli,Martina Manera,Andrea Mancini,Arianna Battisti,Vittorio Sambri

Diagnostic microbiology and infectious disease（2021）

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摘要

Five SARS-CoV-2-positive samples showed N-gene drop-out with a RT-PCR multiplex test. WGS found all samples to harbor a deletion in the same region of the N gene, which is likely to impair the efficiency of amplification. This highlights the need for a continued surveillance of viral evolution and diagnostic test performance.

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