The JAK inhibitor baricitinib inhibits oncostatin M induction of proinflammatory mediators in ex-vivo synovial derived cells.

Sam Weston, Joanne L Macdonald,Lynn M Williams,Euthalia Roussou,Norbert V Kang,Serafim Kiriakidis,Peter C Taylor

Clinical and experimental rheumatology（2022）

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摘要

These findings are consistent with known signalling pathways employed by OSM, TNFα and IL-1β, but our data suggest that in HSF, baricitinib may have anti-inflammatory effects via downstream modulation of cytokines and chemokines produced in response to TNFα or IL-1β.

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关键词

baricitinib, JAK inhibitor, cytokines, rheumatoid arthritis, pathology, signalling, synoviocytes

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